Bulk ATAC-Seq Analysis Services

(A) Schematic of Library preparation

(B) Visual of transposition results in fragmented DNA. Adapters have to be completed with a 72°C extension step prior to amplification. Then, during PCR, additional sequence is incorporated into the adapters (including common sequencing ends and a sequencing barcode).

At SeqMatic, bioinformatic analysis services of bulk ATAC-seq applications include:

• Nucleosome mapping for identification of nucleosome positions and occupancy across the genome.
• Transcription factor binding analysis to enable the identification of transcription factor binding sites and the study of their role in gene regulation.
• Novel enhancer identification to study enhancer’s role in gene expression.
• Exploration of disease-relevant regulatory mechanisms to understand the role of chromatin accessibility in complex diseases.
• Cell type-specific regulation analysis to provide insights into cell type-specific regulatory mechanisms.
• Evolutionary studies to understand the evolution of chromatin accessibility across different species.
• Comparative epigenomics to compare profiles between different cell types or conditions.
• Biomarker discovery to identify potential biomarkers associated with specific diseases or conditions