PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib

Home > PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib

PARP1-SNAI2 transcription axis drives resistance to PARP inhibitor, Talazoparib

Final libraries were sequenced by SeqMatic (44846 Osgood Rd, Fremont, CA 94539) using Illumina NovaSeq 6000 system, with 2 × 75 paired-end kits.

body{opacity:0}img:is([sizes=auto i],[sizes^="auto," i]){contain-intrinsic-size:3000px 1500px}img.wp-smiley,img.emoji{display:inline !important;border:none !important;box-shadow:none !important;height:1em !important;width:1em !important;margin:0 .07em !important;vertical-align:-.1em !important;background:none !important;padding:0 !important}.wp-block-audio :where(figcaption){color:#555;font-size:13px;text-align:center}.is-dark-theme .wp-block-audio :where(figcaption){color:rgba(255,255,255,.65)}.wp-block-audio{margin:0 0 1em}.wp-block-code{border:1px solid #ccc;border-radius:4px;font-family:Menlo,Consolas,monaco,monospace;padding:.8em 1em}.wp-block-embed :where(figcaption){color:#555;font-size:13px;text-align:center}.is-dark-theme .wp-block-embed :where(figcaption){color:rgba(255,255,255,.65)}.wp-block-embed{margin:0 0 1em}.blocks-gallery-caption{color:#555;font-size:13px;text-align:center}.is-dark-theme .blocks-gallery-caption{color:rgba(255,255,255,.65)}:root :where(.wp-block-image figcaption){color:#555;font-size:13px;text-align:center}.is-dark-theme :root :where(.wp-block-image figcaption){color:rgba(255,255,255,.65)}.wp-block-image{margin:0 0 1em}.wp-block-pullquote{border-bottom:4px solid;border-top:4px solid;color:currentColor;margin-bottom:1.75em}.wp-block-pullquote :where(cite),.wp-block-pullquote :where(footer),.wp-block-pullquote__citation{color:currentColor;font-size:.8125em;font-style:normal;text-transform:uppercase}.wp-block-quote{border-left:.25em solid;margin:0 0 1.75em;padding-left:1em}.wp-block-quote cite,.wp-block-quote footer{color:currentColor;font-size:.8125em;font-style:normal;position:relative}.wp-block-quote:where(.has-text-align-right){border-left:none;border-right:.25em solid;padding-left:0;padding-right:1em}.wp-block-quote:where(.has-text-align-center){border:none;padding-left:0}.wp-block-quote.is-large,.wp-block-quote.is-style-large,.wp-block-quote:where(.is-style-plain){border:none}.wp-block-search .wp-block-search__label{font-weight:700}.wp-block-search__button{border:1px solid #ccc;padding:.375em .625em}:where(.wp-block-group.has-background){padding:1.25em 2.375em}.wp-block-separator.has-css-opacity{opacity:.4}.wp-block-separator{border:none;border-bottom:2px solid;margin-left:auto;margin-right:auto}.wp-block-separator.has-alpha-channel-opacity{opacity:1}.wp-block-separator:not(.is-style-wide):not(.is-style-dots){width:100px}.wp-block-separator.has-background:not(.is-style-dots){border-bottom:none;height:1px}.wp-block-separator.has-background:not(.is-style-wide):not(.is-style-dots){height:2px}.wp-block-table{margin:0 0 1em}.wp-block-table td,.wp-block-table th{word-break:normal}.wp-block-table :where(figcaption){color:#555;font-size:13px;text-align:center}.is-dark-theme .wp-block-table :where(figcaption){color:rgba(255,255,255,.65)}.wp-block-video :where(figcaption){color:#555;font-size:13px;text-align:center}.is-dark-theme .wp-block-video :where(figcaption){color:rgba(255,255,255,.65)}.wp-block-video{margin:0 0 1em}:root :where(.wp-block-template-part.has-background){margin-bottom:0;margin-top:0;padding:1.25em 2.375em}.wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none}:root{--wp--preset--aspect-ratio--square:1;--wp--preset--aspect-ratio--4-3:4/3;--wp--preset--aspect-ratio--3-4:3/4;--wp--preset--aspect-ratio--3-2:3/2;--wp--preset--aspect-ratio--2-3:2/3;--wp--preset--aspect-ratio--16-9:16/9;--wp--preset--aspect-ratio--9-16:9/16;--wp--preset--color--black:#000;--wp--preset--color--cyan-bluish-gray:#abb8c3;--wp--preset--color--white:#fff;--wp--preset--color--pale-pink:#f78da7;--wp--preset--color--vivid-red:#cf2e2e;--wp--preset--color--luminous-vivid-orange:#ff6900;--wp--preset--color--luminous-vivid-amber:#fcb900;--wp--preset--color--light-green-cyan:#7bdcb5;--wp--preset--color--vivid-green-cyan:#00d084;--wp--preset--color--pale-cyan-blue:#8ed1fc;--wp--preset--color--vivid-cyan-blue:#0693e3;--wp--preset--color--vivid-purple:#9b51e0;--wp--preset--color--primary:#cc6d36;--wp--preset--color--secondary:#36499b;--wp--preset--color--dark:#333;--wp--preset--color--font:#666;--wp--preset--color--transparent:transparent;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple:linear-gradient(135deg,#0693e3 0%,#9b51e0 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan:linear-gradient(135deg,#7adcb4 0%,#00d082 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange:linear-gradient(135deg,#fcb900 0%,#ff6900 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red:linear-gradient(135deg,#ff6900 0%,#cf2e2e 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray:linear-gradient(135deg,#eee 0%,#a9b8c3 100%);--wp--preset--gradient--cool-to-warm-spectrum:linear-gradient(135deg,#4aeadc 0%,#9778d1 20%,#cf2aba 40%,#ee2c82 60%,#fb6962 80%,#fef84c 100%);--wp--preset--gradient--blush-light-purple:linear-gradient(135deg,#ffceec 0%,#9896f0 100%);--wp--preset--gradient--blush-bordeaux:linear-gradient(135deg,#fecda5 0%,#fe2d2d 50%,#6b003e 100%);--wp--preset--gradient--luminous-dusk:linear-gradient(135deg,#ffcb70 0%,#c751c0 50%,#4158d0 100%);--wp--preset--gradient--pale-ocean:linear-gradient(135deg,#fff5cb 0%,#b6e3d4 50%,#33a7b5 100%);--wp--preset--gradient--electric-grass:linear-gradient(135deg,#caf880 0%,#71ce7e 100%);--wp--preset--gradient--midnight:linear-gradient(135deg,#020381 0%,#2874fc 100%);--wp--preset--font-size--small:15px;--wp--preset--font-size--medium:24px;--wp--preset--font-size--large:30px;--wp--preset--font-size--x-large:42px;--wp--preset--font-size--normal:18px;--wp--preset--font-size--huge:34px;--wp--preset--spacing--20:.44rem;--wp--preset--spacing--30:.67rem;--wp--preset--spacing--40:1rem;--wp--preset--spacing--50:1.5rem;--wp--preset--spacing--60:2.25rem;--wp--preset--spacing--70:3.38rem;--wp--preset--spacing--80:5.06rem;--wp--preset--shadow--natural:6px 6px 9px rgba(0,0,0,.2);--wp--preset--shadow--deep:12px 12px 50px rgba(0,0,0,.4);--wp--preset--shadow--sharp:6px 6px 0px rgba(0,0,0,.2);--wp--preset--shadow--outlined:6px 6px 0px -3px #fff,6px 6px #000;--wp--preset--shadow--crisp:6px 6px 0px #000}:where(.is-layout-flex){gap:.5em}:where(.is-layout-grid){gap:.5em}body .is-layout-flex{display:flex}.is-layout-flex{flex-wrap:wrap;align-items:center}.is-layout-flex > :is(*, div){margin:0}body .is-layout-grid{display:grid}.is-layout-grid > :is(*, div){margin:0}:where(.wp-block-columns.is-layout-flex){gap:2em}:where(.wp-block-columns.is-layout-grid){gap:2em}:where(.wp-block-post-template.is-layout-flex){gap:1.25em}:where(.wp-block-post-template.is-layout-grid){gap:1.25em}.has-black-color{color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-color{color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-color{color:var(--wp--preset--color--white) !important}.has-pale-pink-color{color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-color{color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-color{color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-color{color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-color{color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-color{color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-color{color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-color{color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-color{color:var(--wp--preset--color--vivid-purple) !important}.has-black-background-color{background-color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-background-color{background-color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-background-color{background-color:var(--wp--preset--color--white) !important}.has-pale-pink-background-color{background-color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-background-color{background-color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-background-color{background-color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-background-color{background-color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-background-color{background-color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-background-color{background-color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-background-color{background-color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-background-color{background-color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-background-color{background-color:var(--wp--preset--color--vivid-purple) !important}.has-black-border-color{border-color:var(--wp--preset--color--black) !important}.has-cyan-bluish-gray-border-color{border-color:var(--wp--preset--color--cyan-bluish-gray) !important}.has-white-border-color{border-color:var(--wp--preset--color--white) !important}.has-pale-pink-border-color{border-color:var(--wp--preset--color--pale-pink) !important}.has-vivid-red-border-color{border-color:var(--wp--preset--color--vivid-red) !important}.has-luminous-vivid-orange-border-color{border-color:var(--wp--preset--color--luminous-vivid-orange) !important}.has-luminous-vivid-amber-border-color{border-color:var(--wp--preset--color--luminous-vivid-amber) !important}.has-light-green-cyan-border-color{border-color:var(--wp--preset--color--light-green-cyan) !important}.has-vivid-green-cyan-border-color{border-color:var(--wp--preset--color--vivid-green-cyan) !important}.has-pale-cyan-blue-border-color{border-color:var(--wp--preset--color--pale-cyan-blue) !important}.has-vivid-cyan-blue-border-color{border-color:var(--wp--preset--color--vivid-cyan-blue) !important}.has-vivid-purple-border-color{border-color:var(--wp--preset--color--vivid-purple) !important}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background:var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background:var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background:var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background:var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background:var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important}.has-cool-to-warm-spectrum-gradient-background{background:var(--wp--preset--gradient--cool-to-warm-spectrum) !important}.has-blush-light-purple-gradient-background{background:var(--wp--preset--gradient--blush-light-purple) !important}.has-blush-bordeaux-gradient-background{background:var(--wp--preset--gradient--blush-bordeaux) !important}.has-luminous-dusk-gradient-background{background:var(--wp--preset--gradient--luminous-dusk) !important}.has-pale-ocean-gradient-background{background:var(--wp--preset--gradient--pale-ocean) !important}.has-electric-grass-gradient-background{background:var(--wp--preset--gradient--electric-grass) !important}.has-midnight-gradient-background{background:var(--wp--preset--gradient--midnight) !important}.has-small-font-size{font-size:var(--wp--preset--font-size--small) !important}.has-medium-font-size{font-size:var(--wp--preset--font-size--medium) !important}.has-large-font-size{font-size:var(--wp--preset--font-size--large) !important}.has-x-large-font-size{font-size:var(--wp--preset--font-size--x-large) !important}:where(.wp-block-post-template.is-layout-flex){gap:1.25em}:where(.wp-block-post-template.is-layout-grid){gap:1.25em}:where(.wp-block-term-template.is-layout-flex){gap:1.25em}:where(.wp-block-term-template.is-layout-grid){gap:1.25em}:where(.wp-block-columns.is-layout-flex){gap:2em}:where(.wp-block-columns.is-layout-grid){gap:2em}:root :where(.wp-block-pullquote){font-size:1.5em;line-height:1.6}.woocommerce form .form-row .required{visibility:visible}.e-con.e-parent:nth-of-type(n+4):not(.e-lazyloaded):not(.e-no-lazyload),.e-con.e-parent:nth-of-type(n+4):not(.e-lazyloaded):not(.e-no-lazyload) *{background-image:none !important}@media screen and (max-height: 1024px){.e-con.e-parent:nth-of-type(n+3):not(.e-lazyloaded):not(.e-no-lazyload),.e-con.e-parent:nth-of-type(n+3):not(.e-lazyloaded):not(.e-no-lazyload) *{background-image:none !important}.e-con.e-parent:nth-of-type(n+3):not(.e-lazyloaded):not(.e-no-lazyload).nitro-lazy,.e-con.e-parent:nth-of-type(n+3):not(.e-lazyloaded):not(.e-no-lazyload) *.nitro-lazy{background-image:none !important}}@media screen and (max-height: 640px){.e-con.e-parent:nth-of-type(n+2):not(.e-lazyloaded):not(.e-no-lazyload),.e-con.e-parent:nth-of-type(n+2):not(.e-lazyloaded):not(.e-no-lazyload) *{background-image:none !important}.e-con.e-parent:nth-of-type(n+2):not(.e-lazyloaded):not(.e-no-lazyload).nitro-lazy,.e-con.e-parent:nth-of-type(n+2):not(.e-lazyloaded):not(.e-no-lazyload) *.nitro-lazy{background-image:none !important}}.e-con.e-parent:nth-of-type(n+4):not(.e-lazyloaded):not(.e-no-lazyload).nitro-lazy,.e-con.e-parent:nth-of-type(n+4):not(.e-lazyloaded):not(.e-no-lazyload) *.nitro-lazy{background-image:none !important}@media (max-width: 991px){div.title-lg-center .title{margin-left:auto;margin-right:auto;text-align:center}div.title-lg-left .title{margin-right:auto;margin-left:0;text-align:left}div.title-lg-right .title{margin-left:auto;margin-right:0;text-align:right}}@media (max-width: 767px){div.title-md-center .title{margin-left:auto;margin-right:auto;text-align:center}div.title-md-left .title{margin-right:auto;text-align:left;margin-left:0}div.title-md-right .title{margin-left:auto;margin-right:0;text-align:right}}.nowrap-col .elementor-widget-wrap{flex-wrap:nowrap}.custom-header{position:absolute;top:0;left:0;right:0;background:transparent;z-index:11}.custom-header .sticky-content.fixed{border-bottom-width:0}.menu-active-underline>li>a:before{border-width:1px;bottom:21px}@media (max-width:1199px){.main-menu .menu>li:not(:last-child){margin-right:2.5rem}}@media (max-width:767px){.custom-top-list .elementor-icon-list-item .elementor-icon-list-text,.custom-account span{display:none}.custom-header-search .search-toggle i{margin-right:0;font-size:2rem}.custom-top-list.elementor-element .elementor-icon-list-items li.elementor-icon-list-item:not(:last-child):after{content:none}}@media (max-width:1199px){.cs-search .search-toggle span{display:none}}.custom-contact-info p{margin-bottom:0;line-height:1.72}.custom-contact-info strong{font-weight:500;color:#e1e1e1}.custom-contact .info-box.info-box-side{justify-content:flex-start}.custom-width{max-width:315px}.custom-wpforms .wpforms-container .wpforms-form .wpforms-submit-container button.wpforms-submit{padding:1.25rem 2rem;border:1px solid rgba(153,153,153,.4) !important;border-left:0 !important;border-radius:0 .5rem .5rem 0}.custom-wpforms .wpforms-container .wpforms-field-container .wpforms-field input.wpforms-field-large{border-right:0;border-radius:.5rem 0 0 .5rem}.wpforms-submit-icon.wpforms-submit:after{font-size:1.8rem}.custom-wpforms p{font-size:1.4rem}@media ( max-width: 1199px ){.member-info .post-media,.member-info img{width:15rem;height:15rem}}.elementor-widget:not(:last-child){margin-bottom:0px !important}li.elementor-icon-list-item{list-style-type:none !important}.custom_whatwedo:nth-child(odd) .elementor-widget-wrap.elementor-element-populated{display:flex;flex-wrap:wrap;width:100%;flex-direction:row-reverse}.custom_whatwedo:nth-child(odd) .custom-banner{right:unset;left:0}.custom_whatwedo:nth-child(odd) .custom-banner{right:unset;left:0}.custom_services_grid .flipbox_back{padding:1.5rem 1rem 1.5rem 1.5rem}.custom_services_grid .flipbox-icon svg{border-radius:50%}.custom_services_grid .flipbox .flipbox_front .flipbox-title{color:#36499c}.custom_services_grid .flipbox .flipbox-title{font-size:1.6rem;margin:0}.custom_services_grid .flipbox_back .flipbox-content{transform:inherit !important}.custom_services_grid .flipbox_back .flipbox-subtitle{font-size:1.5rem;margin-bottom:1rem}.custom_services_grid .flipbox_back *{color:#fff}.custom_services_grid .flipbox_back ul{padding-left:15px;margin-bottom:0}.custom_services_grid .flipbox_back li,.custom_services_grid .flipbox_back p{font-size:1.2rem;line-height:1.3;margin-bottom:5px}.custom_services_grid .flipbox_back .btn{margin-top:10px}.menu ul .menu-item>a span{color:#826ec3}.custom_homeslider .banner-img{position:relative}.custom_success .elementor-element.elementor-button-success .elementor-button{background-color:#409ed0}.custom_overlay .banner-img{position:relative}.custom_overlay .banner-img:before{content:"";width:100%;height:100%;left:0;top:0;background:rgba(0,0,0,.3);position:absolute}.custom_faq .elementor-accordion-item:first-of-type{display:none}body .custom_faq .elementor-widget-container{box-shadow:none !important;border-radius:0 !important}.custom_faq .elementor-accordion-item{border:1px solid #e1e1e1 !important;border-radius:8px;margin-bottom:20px}.custom_faq .elementor-accordion-item .elementor-tab-title{padding:26px 25px 24px 30px !important}.custom_faq .elementor-accordion-item .elementor-tab-content{padding:15px 25px 15px 30px !important;border-top:none !important}.custom_faq .elementor-tab-title .elementor-accordion-title{color:#32499c !important}.custom_faq .elementor-accordion-item .elementor-tab-title i:before{color:#32499c !important}.custom_faq .elementor-accordion-item .elementor-tab-title.elementor-active .elementor-accordion-title,.custom_faq .elementor-accordion-item .elementor-tab-title:hover .elementor-accordion-title,.custom_faq .elementor-accordion-item .elementor-tab-title.elementor-active i:before,.custom_faq .elementor-accordion-item .elementor-tab-title:hover i:before{color:#cc6d36 !important}.custom_sidebar .widget h2,.custom_sidebar .widget h2 a{color:#000}.custom_sidebar .widget h2:hover,.custom_sidebar .widget h2:hover a{color:#cc6d36}ul.nav.nav-tabs.tabs.tab-nav-separated li#tab-title-additional_information{display:none}.breadcrumb-wrap{display:none}.page-id-3303 .main#main{padding-bottom:0px}.summary .add-to-compare{display:none !important}.single-product a.social-icon.framed.use-hover.social-pinterest{display:none}.single-product a.social-icon.framed.use-hover.social-instagram{display:none}.main#main{padding-bottom:0px !important}.custom-p-details-inner .elementor-container > .banner-content{transform:translate(-50%,-50%) !important}.custom-services-guidelines-banner .elementor-container > .banner-content{transform:translate(-50%,-50%) !important}.custom-products-wireframe-banner .elementor-container > .banner-content{transform:translate(-50%,-50%) !important}.custom-products-wireframe-banner .banner-content.t-c.elementor-column.elementor-col-100.elementor-top-column.elementor-element.elementor-element-65f12b4{bottom:0rem !important}.custom-flipbox-inner ul{text-align:left;color:#fff}.custom-flipbox-inner p{text-align:left}.custom-flipbox-inner p.flipbox-description{padding-left:20px;padding-right:20px}.elementor-shortcode span a{color:#36499b !important;z-index:9999}.custom_hidesection{display:none !important}@media screen and (min-width: 1024px){.hidedesktop{display:none}}@media screen and (max-width: 1024px){.main-menu li:nth-child(6){display:list-item}}.color-dark,.color-dark *{color:#002d57 !important}.elementor-shortcode a{color:#36499b !important;font-weight:bold}.elementor-shortcode a:hover,.elementor-shortcode a:focus{color:#854923 !important}.elementor-shortcode a{color:#36499b !important;font-weight:bold}.elementor-shortcode a:hover,.elementor-shortcode a:focus{color:#854923 !important}#rs-demo-id{}

Articles & Blog Forums

Advancing MedTech Histopathology: Expanding Capabilities at SeqMatic

SeqMatic Forum: Finding the Right Data to Generate

SeqMatic Forum: Finding the Right Histopathology Pipeline

SeqMatic Forum: Finding the Right Preclinical Model to Evaluate Medical Devices Pathology

SeqMatic Forum: GxP, CLIA & CAP Guidelines for Reliability & Data Integrity

SeqMatic Forum: Histopathology Use Case Within ISO Guidelines

SeqMatic Forum: Device Classification of ISO 10993-1

SeqMatic Forum: Leading Use Cases For MedTech Histopathology